绝经后女性骨密度与冠状动脉钙化的相关性研究.

Objective The present study was designed to evaluate the relationship between bone mineral density (BMD) and coronary artery calcification (CAC) in postmenopausal women. Methods Participants included 120 postmenopausal women older than 55 years. Clinical data of each participant was collected. Serum total glyceride (TG), low-density lipoprotein cholesterol (LDL-C), high- density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), calcium, and phosphate were measured. BMD of the hip and lumbar vertebrae 1-4 was detected using dual energy X-ray absorptiometry. CAC was measured with high-definition computerized tomography. Results There was a significant negative correlation between age and BMD of the left femoral neck and lumbar vertebrae 1-4 (P<0.05). For CAC, there was a moderately positive correlation between age and volume and mass scores. CAC was present in 66% of participants. There was no significant correlation between all kinds of CAC scores including calcification and volume and mass scores, and BMD of all scanned body parts including lumbar spine 1-4 and femoral neck (P>0.05). Furthermore, multiple linear regression analysis showed that the relationship between CAC scores and BMD remained no statistically significant (P>0.05). Conclusion Age is an important factor for decrease of BMD and development of CAC detected by HDCT. [ABSTRACT FROM AUTHOR]