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A New Hemicyanine-based Fluorophore for Monitoring pH and Lysosome Imaging.
- Source :
-
Journal of Analytical Chemistry . Sep2019, Vol. 74 Issue 9, p940-944. 5p. - Publication Year :
- 2019
-
Abstract
- On account of long wavelength emission and high stability, a hemi-cyanine skeleton of 2,3,3-trimethyl-1-(3-sulfopropyl)-3H-benzo[f]indolinium was condensed with 6-hydroxy-7-morpholin-4-yl-methyl-naphthalene-2-carbaldehyde in the presence of acetic anhydride. The new probe displays a sensitive absorption and fluorescence according to the pH value changes and exhibits an excellent linearity of the relative emission intensity (I670/I580) vs. pH in the pH range of 7.0–9.5 with a correlation coefficient of 0.993. Moreover, compared to the commercialized LysoTracker Green DND-26 the probe is targeting to the lysosomal imaging in HeLa cells and, thus, can be further used as a near-infrared fluorescent probe for cellular research. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10619348
- Volume :
- 74
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Journal of Analytical Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 138226588
- Full Text :
- https://doi.org/10.1134/S1061934819090119