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Antitumor, Antiviral, and Anti-Inflammatory Efficacy of Essential Oils from Atractylodes macrocephala Koidz. Produced with Different Processing Methods.

Authors :
Gu, Sihao
Li, Ling
Huang, Hai
Wang, Bing
Zhang, Tong
Jeliazkov, Valtcho
Isman, Murray B
Chemat, Farid
Bankova, Vassya
Radulović, Niko
Source :
Molecules. Aug2019, Vol. 24 Issue 16, p2956-2956. 1p. 1 Chart, 4 Graphs.
Publication Year :
2019

Abstract

Atractylodes macrocephala Koidz. has been used as an invigorating spleen drug for eliminating dampness and phlegm in China. According to recent researches, different processing methods may affect the drug efficacy, so we collected A. macrocephala from the Zhejiang Province, produced with different processing methods, crude A. macrocephala (CA) and bran-processed A. macrocephala (BA), then analyzed its essential oils (EOs) by GC/MS. The results showed 34 components representing 98.44% of the total EOs of CA were identified, and 46 components representing 98.02% of the total EOs of BA were identified. Atractylone is the main component in A. macrocephala. Compared with CA, BA has 46 detected compounds, 28 of which were identical, and 6 undetected compounds. Pharmacodynamic results revealed that the EOs of CA and atractylone exhibited more effective anticancer activity in HepG2, MCG803, and HCT-116 cells than the EOs of BA; while the EOs of BA exhibited simple antiviral effect on viruses H3N2, both the EOs and atractylone show anti-inflammatory activity by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in ANA-1 cells. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14203049
Volume :
24
Issue :
16
Database :
Academic Search Index
Journal :
Molecules
Publication Type :
Academic Journal
Accession number :
138229738
Full Text :
https://doi.org/10.3390/molecules24162956