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Reaction mechanism of flavin-dependent hydroxylation.
- Source :
-
European Journal of Biochemistry . 10/3/83, Vol. 135 Issue 3, p543-548. 6p. - Publication Year :
- 1983
-
Abstract
- Analysis of the partially refined X-ray crystallographic structure of the active site of p-hydroxybenzoate hydroxylase shows clearly that the enzyme is complementary to a flavin C4,C4a-dioxetane derivative. A mechanism is proposed based on such an intermediate as the oxenoid transferring agent. A non-enzymatic analogue of this reaction is not known in organic chemistry. A possible evolutionary pathway for such a non-imitable enzyme is discussed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00142956
- Volume :
- 135
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- European Journal of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 13838719
- Full Text :
- https://doi.org/10.1111/j.1432-1033.1983.tb07686.x