Photosafety of the antidiabetic drug sitagliptin.

For SIT, PIF value is below 2; indicating that neither UVA radiation nor sunlight affect the toxicity of the compound, and therefore, according to the OECD Guideline,[10] SIT cannot be considered a phototoxic drug. The probability that SIT could have triggered cutaneous lupus in the patient is low because the lesions did not resolve after SIT discontinuation and no case has been reported in the literature related to SIT-induced lupus. Due to both the clinical evaluation of our patient, and the I in vitro i and complementary tests carried out, we have reasonable evidence supporting that SIT is not capable of triggering photosensitivity reactions. [Extracted from the article]