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Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy.
- Source :
-
Chemical Communications . 9/18/2019, Vol. 55 Issue 73, p10892-10895. 4p. - Publication Year :
- 2019
-
Abstract
- Bifunctional supramolecular prodrug vesicles have been successfully constructed based on the complexation between a glutathione (GSH)-responsive prodrug guest molecule (DNS-CPT) and a water-soluble pillar[5]arene (WP5) for cancer diagnosis and therapy. Under the microenvironment of cancer cells with high GSH concentration, 7-ethyl-10-hydroxycamptothecin (SN-38) with strong yellow fluorescence can be efficiently released from the prodrug DNS-CPT for drug location and cancer therapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CANCER diagnosis
*CANCER treatment
*CANCER cells
*FLUORESCENCE
Subjects
Details
- Language :
- English
- ISSN :
- 13597345
- Volume :
- 55
- Issue :
- 73
- Database :
- Academic Search Index
- Journal :
- Chemical Communications
- Publication Type :
- Academic Journal
- Accession number :
- 138522161
- Full Text :
- https://doi.org/10.1039/c9cc05859a