Back to Search
Start Over
2H-Pyranone and isocoumarin derivatives isolated from the plant pathogenic fungus Leptosphaena maculans.
- Source :
-
Journal of Asian Natural Products Research . Oct2019, Vol. 21 Issue 10, p939-946. 8p. - Publication Year :
- 2019
-
Abstract
- Two new 2H-pyranones and two new isocoumarin derivatives, maculanslines A-D (1–4), together with seven known compounds (5–11), were isolated from the plant pathogenic fungus Leptosphaena maculans. Their planar structures and absolute configuration were elucidated by comprehensive spectroscopic techniques including high-resolution electrospray ionization mass spectrum, 1D and 2D nuclear magnetic resonance, as well as electronic circular dichroism. All 11 compounds were tested for their inhibitory activity against α-glucosidase. Compound 1 showed moderate inhibitory activity against α-glucosidase with IC50 of 74.35 μM. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ANIMAL experimentation
*BENZOPYRANS
*BIOLOGICAL assay
*FUNGI
*GASTRIC mucosa
*GLYCOSIDASES
*HIGH performance liquid chromatography
*SMALL intestine
*MOLECULAR structure
*NUCLEAR magnetic resonance spectroscopy
*RATS
*RESEARCH funding
*SPECTROPHOTOMETRY
*THIN layer chromatography
*PLANT extracts
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 21
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 138615528
- Full Text :
- https://doi.org/10.1080/10286020.2018.1485661