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Enantioselective Intramolecular Dearomative Lactonization of Naphthols Catalyzed by Planar Chiral Iodoarene.
- Source :
-
Synthesis . 2019, Vol. 51 Issue 19, p3675-3682. 8p. - Publication Year :
- 2019
-
Abstract
- A series of planar chiral iodoarenes based on [2.2]paracyclophane was synthesized. An efficient asymmetric intramolecular oxidative lactonization of naphthols enabled by a combination of these chiral iodoarenes and m CPBA as oxidant is reported. This reaction proceeds under mild conditions, allowing the formation of spirolactones bearing a tetrasubstituted stereocenter in moderate yields and good enantioselectivity. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PLANAR chirality
*PROCEEDS
*CATALYSIS
*OXIDIZING agents
Subjects
Details
- Language :
- English
- ISSN :
- 00397881
- Volume :
- 51
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Synthesis
- Publication Type :
- Academic Journal
- Accession number :
- 138654545
- Full Text :
- https://doi.org/10.1055/s-0037-1611902