S100A14 在乳腺癌不同分子亚型中表达的临床病理研究.

Objective: Expression and clinicopathological significance of S100 calcium binding protein A14(S100A14) in different molecular subtypes of breast cancer were explored to provide reference for identifying new molecular typing markers. Methods:Breast cancer tissues were taken cases for radical mastectomy patients from January 16, 2013 to 22 May 2014 at the Cancer Hospital Affiliated to the Xiangya Medical College of Central South University & the Cancer Hospital of Hunan province. Using immunohistochemistry to detect the expression of S100A14 in 254 breast cancer tissues, with emphasis on differences expression of the protein in different molecular subtypes of breast carcinoma and its correlation with clinicopathological factors, Kaplan-Meier analysis was applied for the relationship between S100 A14 expression and prognosis of patients with breast cancer. Results: The positive expression of S100 A14 in four molecular subtypes of ER+/PR+/HER2+, ER+/PR+/HER2-, ER-/PR-/HER2+ and ER-/PR-/HER2-breast cancer was 38.5%, 47.1%, 75.5%, 80%, respectively. The expression of the 4 groups was the highest in the ER-/PR-/HER2-type and the lowest in the ER+/PR+/HER2+ type, and the difference between the 4 groups was significant(x2=32.997, P <0.001). The relationship between S100A14 and clinicopathological characteristics of 254 cases of breast cancer was analyzed. The expression of S100A14 was significantly negatively correlated with the expression of ER and PR(all r=-0.353, P<0.001), and was significantly positively correlated with postoperative recurrence of liver metastasis with breast cancer(r=0.134, P=0.040). There is no significant correlation between the expression of S100A14 and the clinicopathological features of type ER+/PR+/HER2+ and ER+/PR+/HER2-type breast cancer(P>0.05).In ER-/PR-/HER2+ type breast cancer. The positive expression rate of S100 A14 in axillary lymph node metastasis group was significantly higher than that without axillary lymph node metastasis group(x2=6.768, P=0.013), and S100A4 expression has a negative correlation with postoperative pulmonary metastasis(r=-0.272, P=0.044). Conclusion: The expression of S100A14 in breast cancer with different molecular subtypes is different, and its high expression is associated with metastasis or recurrence of breast cancer with different molecular types. It may be used as a candidate marker for molecular typing of breast cancer. [ABSTRACT FROM AUTHOR]