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Oral immunotherapy with peach juice in patients allergic to LTPs.
- Source :
-
Allergy, Asthma & Clinical Immunology . 9/24/2019, Vol. 15 Issue 1, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
-
Abstract
- Introduction: To assess the safety and efficacy of an oral immunotherapy regimen in patients with allergy to lipid transfer proteins (LTPs). Materials and methods: Prospective study of 24 patients allergic to LTP with positive skin test and a history of anaphylaxis. All patients underwent a desensitization protocol with commercial peach juice. Rising doses of peach juice were administered, starting with an initial dose of seven drops of a 1/1000 dilution and finishing with a dose of 5 ml at visit 17. At visit 18, all patients performed an open challenge with whole juice at a cumulative dose of 200 ml. All adverse reactions occurring during the administration of the different doses were recorded. Levels of rPru p 3 in the juice were quantified. Results: There were no severe reactions during the desensitization process in the 24 patients. Seven patients (29%) reported mild oral symptoms, and two patients (8%) had urticaria associated with co-factors (one due to exercise and another due to non-steroidal anti-inflammatory drugs). Nineteen patients were able to swallow 5 ml of juice and five withdrew from the study. In two pregnant patients the final challenge was not performed. In all, 17/24 patients were able to consume 200 ml peach juice without developing symptoms. Conclusions: Oral immunotherapy with the regimen used in this study is an effective and safe short-term therapeutic option for patients with allergy to LTPs. Commercial peach juice appears to be suitable for this treatment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALLERGY desensitization
*LIPID transfer protein
*PEACH
*IMMUNOTHERAPY
*SKIN tests
Subjects
Details
- Language :
- English
- ISSN :
- 17101484
- Volume :
- 15
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Allergy, Asthma & Clinical Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 138792152
- Full Text :
- https://doi.org/10.1186/s13223-019-0374-x