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Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics.

Authors :
Obam Mekanda, Franck-Martin
Monamele, Chavely Gwladys
Simo Nemg, Frédy Brice
Yonga, Gilde Martial
Ouapi, Diane
Penlap Beng, Véronique
Batéjat, Christophe
Caro, Valérie
Manuguerra, Jean-Claude
Demanou, Maurice
Source :
PLoS ONE. 9/25/2019, Vol. 14 Issue 9, p1-10. 10p.
Publication Year :
2019

Abstract

The first genotyping data on measles virus (MeV) strains in Cameroon dates from 1994, while other studies were realized in 2001 and 2011 with the establishment of MeV virological surveillance. However, the genetic data of MeV strains circulating in Cameroon remains fragmented and concentrated in certain regions, hence the need for an update. The objective of this study was to have recent data on MeV genotypes circulating in Cameroon. Ninety throat swabs collected during recent measles outbreaks were analyzed by MeV genotyping RT-PCR using the nucleoprotein gene N. The resulting sequences were analyzed on the basis of 450 nucleotides with MEGA 7 software. Overall genome analysis was performed on 40/90 sequences. The strains were from all ten regions and all belonged to cluster 1 of genotype B3. The genotype B3 has been circulating in Cameroon for long periods of time; efforts must be made in immunization for its elimination. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
19326203
Volume :
14
Issue :
9
Database :
Academic Search Index
Journal :
PLoS ONE
Publication Type :
Academic Journal
Accession number :
138802312
Full Text :
https://doi.org/10.1371/journal.pone.0222428