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Click synthesis of N1-(β-D-ribofuranosyl)-C4-(coumarin-4″-yl)-1,2,3-triazoles.
- Source :
-
Synthetic Communications . 2019, Vol. 49 Issue 22, p3140-3147. 8p. 4 Diagrams, 1 Chart. - Publication Year :
- 2019
-
Abstract
- A series of eight N1-(β-D-ribofuranosyl)-C4-(coumarin-4′′-yl)-1,2,3-triazoles have been synthesized by Cu(I)-catalyzed click reaction of 1-azido-1-deoxy-2,3,5-tri-O-benzoyl-β-D-ribofuranose with differently substituted 4-ethynylcoumarins followed by debenzoylation of the resulted N1-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-C4-(coumarin-4″-yl)-1,2,3-triazoles in 71 to 89% overall yields. The structures of all the synthesized compounds were established on the basis of their spectral data analysis that was further confirmed by X-ray data analysis of one of the model benzoylated compounds, i.e. N1-(2′,3′,5′-tri-O-benzoyl-β-D-ribofuranosyl)-C4-(7″-isopropoxycoumarin-4″-yl)-1,2,3-triazole. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DATA analysis
*CLICK chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 49
- Issue :
- 22
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 138813033
- Full Text :
- https://doi.org/10.1080/00397911.2019.1657150