AGE AT ONSET CHARACTERISTICS OF BIPOLAR DISORDER IN A COHORT OF 13,700 PATIENTS.

B Abstract: b Early age at onset (AAO) is associated with an unfavourable clinical outcome. BD and schizophrenia (SCZ) multiplex families can show a high number of early AAO cases, suggesting a genetic contribution to early AAO. Previous GWAS did not identify AAO-associated variants for BD, indicating that larger samples and a more accurately defined AAO phenotype are required for the detection of AAO-associated common variants. [Extracted from the article]