S29ACCELERATED CORTICAL THINNING AND VOLUME REDUCTION OVER TIME IN YOUNG PEOPLE AT HIGH GENETIC RISK FOR BIPOLAR DISORDER.

B Background: b Bipolar disorder (BD) is a familial psychiatric disorder associated with fronto-limbic brain abnormalities. B Results: b Over time, the HR group, as compared to the control group, showed accelerated cortical thinning and volume reduction in a number of right lateralised frontal regions: inferior frontal gyrus, lateral orbitofrontal cortex, frontal pole, and rostral middle frontal gyrus. Independent of time, the HR group had significantly greater cortical thickness in the left caudal anterior cingulate cortex, and larger volume in the right medial orbitofrontal cortex and right accumbens area compared to controls. [Extracted from the article]