S46A GENOME-WIDE ASSOCIATION STUDY OF THE LONGITUDINAL COURSE OF EXECUTIVE FUNCTIONS.

B Background: b Executive functions, i.e. cognition involving control and coordination of mental processes, are impaired in severe mental disorders. To fully take advantage of the PsyCourse sample, we included all genotyped patients and healthy control individuals which had at least one measurement point and performed linear mixed model (LMM) analyses to study the interactions of SNP and time on a genome-wide level. B Results: b In our preliminary analysis, nine SNPs reached genome-wide significance (5 × 10^-8) for the phenotype TMT-B, located within the same LD block (r^2>0.85) on chromosome 5. [Extracted from the article]