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Common methodological pitfalls and new developments in systematic review meta‐analyses.

Authors :
Leonardi‐Bee, J.
Flohr, C.
Zuuren, E. J.
Le Cleach, L.
Hollestein, L.M.
Source :
British Journal of Dermatology. Oct2019, Vol. 181 Issue 4, p649-651. 3p.
Publication Year :
2019

Abstract

Systematic reviews have become an increasingly popular tool to assess best evidence and have an established place at the top of the evidence pyramid, above individual randomized controlled trials (RCTs). Meta-analyses are useful as they provide estimates of effect from more than one study and therefore will have increased statistical power (through larger sample size) and have improved estimates of precision (through smaller standard errors), thus yielding narrower confidence intervals (CIs) for the effect estimate; therefore, the more certain we are that the effect estimate reflects the true effect size. It is important to remember that subgroup and sensitivity analyses are observational associations, not causal, as any observed effect could be due to confounding, bias or chance. [Extracted from the article]

Subjects

Subjects :
*META-analysis

Details

Language :
English
ISSN :
00070963
Volume :
181
Issue :
4
Database :
Academic Search Index
Journal :
British Journal of Dermatology
Publication Type :
Academic Journal
Accession number :
138896684
Full Text :
https://doi.org/10.1111/bjd.18336