Back to Search
Start Over
Serum albumin and hospitalization among pediatric patients with end-stage renal disease who started dialysis therapy.
- Source :
-
Pediatric Nephrology . Oct2019, Vol. 34 Issue 10, p1799-1809. 11p. 1 Diagram, 2 Charts, 5 Graphs. - Publication Year :
- 2019
-
Abstract
- Background: Hypoalbuminemia is a strong predictor of hospitalization and mortality among adult dialysis patients. However, data are scant on the association between serum albumin and hospitalization among children new to dialysis. Methods: In a retrospective cohort study of children 1–17 years old with end-stage renal disease receiving dialysis therapy in a large US dialysis organization 2007–2011, we examined the association of serum albumin with hospitalization frequency and total hospitalization days using a negative binomial regression model. Results: Among 416 eligible patients, median (interquartile range) age was 14 (10–16) years and mean ± SD baseline serum albumin level was 3.7 ± 0.8 g/dL. Two hundred sixty-six patients (64%) were hospitalized during follow-up with an incidence rate of 2.2 (95%CI, 1.9–2.4) admissions per patient-year. There was a U-shaped association between serum albumin and hospitalization frequency; hospitalization rates (95%CI) were 2.7 (2.2–3.2), 1.9 (1.5–2.4), 1.6 (1.3–1.9), and 2.7 (1.7–3.6) per patient-year among patients with serum albumin levels < 3.5, 3.5– < 4.0, 4.0– < 4.5, and ≥ 4.5 g/dL, respectively. Case mix-adjusted hospitalization incidence rate ratios (IRRs) (95%CI) were 1.63 (1.24–2.13), 1.32 (1.10–1.58), and 1.25 (1.06–1.49) at serum albumin levels 3.0, 3.5, and 4.5 g/dL, respectively (reference: 4.0 g/dL). Similar trends were observed in hospitalization days. These associations remained robust against further adjustment for laboratory variables associated with malnutrition and inflammation. Conclusions: Both high and low serum albumin were associated with higher hospitalization in children starting dialysis. Because the observed association is novel and not fully explainable especially for high serum albumin levels, interpreting the results requires caution and further studies are needed to confirm and elucidate this association before clinical recommendations are made. [ABSTRACT FROM AUTHOR]
- Subjects :
- *TREATMENT of chronic kidney failure
*INFLAMMATION
*HOSPITAL care of children
*CONFIDENCE intervals
*HEMODIALYSIS
*HOSPITAL admission & discharge
*LONGITUDINAL method
*PATIENTS
*PEDIATRICS
*REGRESSION analysis
*RISK assessment
*SERUM albumin
*HOSPITAL care of teenagers
*DISEASE incidence
*RETROSPECTIVE studies
*ODDS ratio
BLOOD protein disorder diagnosis
MALNUTRITION risk factors
MORTALITY risk factors
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 34
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 138911359
- Full Text :
- https://doi.org/10.1007/s00467-019-04270-2