Determination and correlation of solubility and solution thermodynamics of musk ketone in twelve pure solvents.

In this study, isothermal saturation method was used to measure and correlate the solubility of musk ketone in twelve organic solvents at temperatures ranging from 278.15 K to 318.15 K, including methanol, ethanol, isopropanol, n-butanol, cyclohexane, n-hexane, n-heptane, N,N -dimethylformamide, N,N -dimethylacetamide, ethyl acetate, tetrahydrofuran and acetonitrile. The experimental results shown that the solubility of musk ketone in the selected solvent increases with increasing temperature. The experimental data were correlated by five thermodynamic models (Wilson model, NRTL model, Vant't Hoff equation, modified Apelblat equation and λh equation), all of the models can give a satisfactory correlation. In addition, mixed thermodynamic properties of Gibbs energy, enthalpy and entropy of musk ketone in selected solvents were calculated based on Wilson model. It can be seen that the dissolution of musk ketone in a given solvent is spontaneous and entropy driven. Exploring the solubility of musk ketone in different organic solvents and the thermodynamics of dissolution can provide basic data for industrial crystallization separation. • The solubility of musk ketone in twelve organic solvents was measured. • Analysis of musk ketone by DSC and XRD. • Vant't Hoff, modified Apelblat, λh, Wilson, and NRTL model were used to correlate the solubility data. • The mixed Gibbs energy, enthalpy and entropy were calculated according to Wilson model. [ABSTRACT FROM AUTHOR]