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Non-enzymatic electrochemical determination of creatinine using a novel screen-printed microcell.
- Source :
-
Talanta . Jan2020, Vol. 207, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- A low-cost and disposable microcell was constructed with a screen-printed electrode for the non-enzymatic electrochemical determination of creatinine. The working electrode was modified with carbon black and maintained in contact with paper-adsorbed iron (III) ions. A small sample volume of 3 μL was required for the device operation. Then, iron (III) ions were complexed in the presence of creatinine in a chemical step, followed by an electrochemical reduction of non-complexed metallic ions in excess. Cyclic voltammetry and differential-pulse voltammetry experiments were employed for the electrochemical characterizations and analytical performance evaluation of the microcell. The working electrode modification with carbon black provided a significant increase of analytical signal. The sensor presented a linear response for creatinine concentrations ranging from 0.10 to 6.5 mmol L−1, with a limit of detection of 0.043 mmol L−1. Experiments for creatinine determination in real samples were successful performed through of standard recovery in urine. Image 1 • Creatinine was determinate by a non-enzymatic, low-cost, and disposable microcell. • A small urine sample volume of 3 μL was required for the operation of the device. • The working electrode modification with carbon black provided a significant increase of analytical signal. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00399140
- Volume :
- 207
- Database :
- Academic Search Index
- Journal :
- Talanta
- Publication Type :
- Academic Journal
- Accession number :
- 138983411
- Full Text :
- https://doi.org/10.1016/j.talanta.2019.120277