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Serum Periostin Level Has Limited Usefulness as a Biomarker for Allergic Disease in 7-Year-Old Children.
- Source :
-
International Archives of Allergy & Immunology . 2019, Vol. 180 Issue 3, p195-201. 7p. 1 Diagram, 4 Charts, 1 Graph. - Publication Year :
- 2019
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Abstract
- Background: Previous studies have used serum periostin levels as a biomarker of Th2-driven inflammatory responses. However, no population-based study has yet examined the association of serum periostin levels with the allergic status of children. Objectives: The aim of this study was to determine the usefulness of periostin as a biomarker for allergy in a group of 7-year-old Korean children. Method: This prospective cross-sectional study examined 451 children (aged 7 years to 7 years and 11 months) from the general pediatric population who attended 6 different schools between June and July 2016. A total of 249 children, all of whom completed the questionnaire and skin prick test and provided blood samples, were included in the final analysis. Results: The geometric mean serum periostin level was 107.6 ng/mL (95% CI 104.5–110.7). After adjustment for confounding, serum periostin levels were significantly associated with sensitization to poly-allergens (adjusted odds ratio, aOR 1.032, 95% CI 1.006–1.059, p = 0.016) and pollen (aOR 1.020, 95% CI 1.002–1.039, p = 0.026). Serum periostin levels were also associated with eosinophil levels (adjusted β = 0.023, SE = 0.009, p = 0.010), but were unrelated to body mass index, sex, obesity, or presence of an allergic disease. Conclusions: Our results suggest thatserum periostin level may have limited usefulness as a biomarker of allergic disease in children. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10182438
- Volume :
- 180
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- International Archives of Allergy & Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 139409083
- Full Text :
- https://doi.org/10.1159/000501224