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Molecular and biological characteristics of the infectious bronchitis virus TC07-2/GVI-1 lineage isolated in China.
- Source :
-
Infection, Genetics & Evolution . Nov2019, Vol. 75, pN.PAG-N.PAG. 1p. - Publication Year :
- 2019
-
Abstract
- In the present study, a thorough comparison of the infectious bronchitis virus (IBV) TC07–2/GVI-1 linage was conducted by comparing the S1 gene sequences of GVI-1 viruses with those of viruses representing the established genotypes and lineages. IBV GVI-1 strains were found to be closely genetically related to each other, irrespective of where the viruses were isolated, and differed from other known IBV genotypes and lineages; thus, it was confirmed that GVI represents a novel genotype. However, the GVI-1 viruses exhibited variable antigenicity when compared to each other. Further analysis found that strains CO8089L and CO8091L, which were isolated in Colombia in 2003, were closely related to GVI-1 viruses, suggesting that GVI-1 viruses likely originated from Colombia and are prevalent in at least five countries (Colombia, China, the Republic of Korea, Japan, and Vietnam). Analysis of the complete GVI-1 virus genomes suggested that the GVI-1 strains in China may be independently derived from recombination events that occurred between GI-19 strains and CO8089L/CO8091L-like viruses following the introduction of the viruses from Colombia. Similar to the viruses isolated in the Republic of Korea, GVI-1 viruses isolated in China also showed an affinity for the respiratory tract of chickens, which differed from one of the deduced parental viruses, the GI-19 strain. This difference may be due to recombination events that occurred in the genomes of the GVI-1 viruses, resulting in the replacement of the spike gene sequences in an YX10-like strain of GI-19 lineage. • GVI-1 viruses likely originated from Columbia. • GVI-1 strains isolated in China may be derived from recombination events between GI-19 and CO8089L/CO8091L-like viruses. • GVI-1 viruses exhibited variable antigenicity. • GVI viruses showed an affinity for the respiratory tract of chickens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AVIAN infectious bronchitis virus
*VIRAL genomes
Subjects
Details
- Language :
- English
- ISSN :
- 15671348
- Volume :
- 75
- Database :
- Academic Search Index
- Journal :
- Infection, Genetics & Evolution
- Publication Type :
- Academic Journal
- Accession number :
- 139437200
- Full Text :
- https://doi.org/10.1016/j.meegid.2019.103942