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LIN28: A cancer stem cell promoter for immunotherapy in head and neck squamous cell carcinoma.
- Source :
-
Oral Oncology . Nov2019, Vol. 98, p92-95. 4p. - Publication Year :
- 2019
-
Abstract
- Lin28, a highly conserved RNA-binding protein, plays an important role in differentiation, metabolism, proliferation, pluripotency, and tumourigenicity. Lin28 overexpression promotes tumour-cell proliferation and metastasis in various human cancers, including head and neck cancer. Multiple studies demonstrate that Lin28 critically contributes to anti-tumour immunity and production of cancer stem cells in head and neck squamous cell carcinoma (HNSCC). Thus, Lin28 has potential application in HNSCC treatment. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13688375
- Volume :
- 98
- Database :
- Academic Search Index
- Journal :
- Oral Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 139472397
- Full Text :
- https://doi.org/10.1016/j.oraloncology.2019.09.024