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Polyadenyllic acid-polyuridylic acid (poly A:U) and experimental murine brucellosis II. MACROPHAGES AS TARGET CELLS OF POLYA:U IN EXPERIMENTAL BRUCELLOSIS.
- Source :
-
Immunology . Jul78, Vol. 35 Issue 1, p77-84. 8p. - Publication Year :
- 1978
-
Abstract
- Results of in vivo and in vitro experiments suggest that the early suppression of brucella growth in double stranded polyadenylic-polyuridylic acid(poly A: U-) treated mice was due to a non-specific activation of macrophages by poly A: U. Poly A: U administered intraperitoneally at the time of brucella infection failed to enhance T-cell mediated responses to the organism, namely delayed-type hypersensitivity to brucellin and adoptive transfer of immunity to the infection. Poly A: U did not augment the protective antibodies formed in response to infection. Although poly A:U has been previously found to suppress brucellosis in athymic (nude) mice, it did not enhance the thymus-dependent antibody response to sheep erythrocytes in brucella-infected nudes, suggesting that it did not significantly enhance maturation of their helper T-cell percursors. Increased macrophage spreading, an indication of activation, was seen immediately after administration of poly A: U and Brucella abortus. Later on the infection spreading was suppressed, a phenomenon which appears to relate to the biphasic effect of poly A: U in vivo described in the accompanying paper. Peritoneal macrophages treated in vitro with poly A: U were stimulated to spread on plastic surfaces, even when T lymphocytes were removed with anti-Thy-1 serum and complement. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00192805
- Volume :
- 35
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 13948351