A one-pot and three-component synthetic approach for the preparation of asymmetric and multi-substituted 1,4-dihydropyrazines.

Authors :: Peytam, Fariba
Adib, Mehdi
Shourgeshty, Reihaneh
Rahmanian-Jazi, Mahmoud
Jahani, Mehdi
Larijani, Bagher
Mahdavi, Mohammad
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Nov2019, Vol. 60 Issue 47, pN.PAG-N.PAG. 1p.
Publication Year :: 2019
Abstract: An efficient, one-pot and three-component synthesis of a new series of 2-acyl-3,4,6-triaryl-1,4-dihydropyrazines is described. This two-step strategy involves treatment of phenacyl bromides and anilines to give the nucleophilic substitution intermediate followed by Michael-addition-cyclization to α -azidochalcones to afford the title compounds in high yields. [ABSTRACT FROM AUTHOR]

Language :: English
ISSN :: 00404039
Volume :: 60
Issue :: 47
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 139526962
Full Text :: https://doi.org/10.1016/j.tetlet.2019.151257

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