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Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population.
- Source :
-
Genetic Testing & Molecular Biomarkers . Nov2019, Vol. 23 Issue 11, p791-796. 6p. - Publication Year :
- 2019
-
Abstract
- Objective: The purpose of this study was to investigate associations between the 14 reported loci (from a meta-analysis of genome-wide association studies [GWAS] in the Caucasian population) and vitiligo in the Chinese Han population. Materials and Methods: In this study 14 single nucleotide polymorphisms (SNPs) at 14 different genetic loci were evaluated for their association with viteligo in a Chinese Han cohort, including 1472 cases and 1472 controls of by using the Sequenom MassArray iPLEX1 system. A Bonferroni adjustment was used for multiple comparisons and pBonferroni <0.0056 was considered statistically significant. Results: The T allele of the locus within the FBXO45-NRROS gene (3q29) was significantly associated with vitiligo (odds ratio = 1.22, 95% confidence interval: 1.10–1.36, p = 0.0001). Association at the genotype level was strong (p = 0.0007). The other SNPs were not associated with vitiligo (pBonferroni >0.0056). Conclusion: A SNP at the rs6583331 locus 3q29 is associated with the susceptibility of vitiligo in the Chinese Han population, which suggests that there is a common genetic factor predisposing to the development of vitiligo in the Chinese and Caucasian populations. [ABSTRACT FROM AUTHOR]
- Subjects :
- *SINGLE nucleotide polymorphisms
*VITILIGO
*ODDS ratio
Subjects
Details
- Language :
- English
- ISSN :
- 19450265
- Volume :
- 23
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Genetic Testing & Molecular Biomarkers
- Publication Type :
- Academic Journal
- Accession number :
- 139529069
- Full Text :
- https://doi.org/10.1089/gtmb.2019.0129