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Urea Derivative Catalyzed Enantioselective Hydroxyalkylation of Hydroxyindoles with Isatins.
- Source :
-
Molecules . Nov2019, Vol. 24 Issue 21, p3944. 1p. 3 Diagrams, 3 Charts. - Publication Year :
- 2019
-
Abstract
- The enantioselective transformations of indoles preferentially take place in the more-reactive azole ring. However, the methods for the enantioselective functionalization of the indole benzene ring are scarce. In this paper, a series of bifunctional (thio)urea derivatives were used to organocatalyze the enantioselective Friedel-Crafts hydroxyalkylation of indoles with isatins. The resulting products were obtained in good yields (65–90%) with up to 94% enantiomer excess (ee). The catalyst type and the substrate scope were broadened in this methodology. [ABSTRACT FROM AUTHOR]
- Subjects :
- *UREA derivatives
*INDOLE
*BENZENE
Subjects
Details
- Language :
- English
- ISSN :
- 14203049
- Volume :
- 24
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Molecules
- Publication Type :
- Academic Journal
- Accession number :
- 139584225
- Full Text :
- https://doi.org/10.3390/molecules24213944