A dual-zwitterion functionalized ultra-hydrophilic metal–organic framework with ingenious synergy for enhanced enrichment of glycopeptides.

A rational strategy was introduced for the synthesis of a novel dual functionalized metal–organic framework nanocomposite (AuGC/ZIF-8) with ultra-hydrophilicity to enhance glycopeptide enrichment. The advantages of ingenious synergy, low-cost, facile and large-scale synthesis, and excellent enrichment performance will enable it to have a bright future in nanomaterial synthesis, glycoproteomics analysis, and related biochemistry. [ABSTRACT FROM AUTHOR]