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Total Synthesis of (−)‐Perezoperezone through an Intermolecular [5+2] Homodimerization of Hydroxy p‐Quinone.
- Source :
-
Angewandte Chemie International Edition . 12/2/2019, Vol. 58 Issue 49, p17552-17557. 6p. - Publication Year :
- 2019
-
Abstract
- The first copper‐catalyzed intermolecular [5+2] homodimerization of hydroxy p‐quinone is presented, furnishing bicyclo[3.2.1]octadienone core structures in typically good yields and excellent diastereoselectivities. Applying this synthetic approach enables a concise nine‐step total synthesis of (−)‐perezoperezone from commercially available 3,5‐dimethoxytoluene. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NATURAL products
*RING formation (Chemistry)
*DIMERIZATION
*QUINONE
Subjects
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 58
- Issue :
- 49
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 139841715
- Full Text :
- https://doi.org/10.1002/anie.201911978