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Efficacy of Cancer Immunotherapy: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials.
- Source :
-
Cancers . Nov2019, Vol. 11 Issue 11, p1801-1801. 1p. - Publication Year :
- 2019
-
Abstract
- We conducted a systematic review for evidence of the clinical efficacy of cancer immunotherapies. We searched PubMed from inception to 14 February 2018 for meta-analyses of randomized controlled trials (RCTs) of cancer immunotherapies. Re-analyses were performed to estimate the summary effect size under random-effects, the 95% confidence interval (CI), heterogeneity, and the 95% prediction interval, and we determined the strength of the evidence. We examined publication bias and excess significance bias. 63 articles corresponding to 247 meta-analyses were eligible. Nine meta-analyses were classified to have convincing evidence, and 75 were classified as suggestive evidence. The clinical benefit of immunotherapy was supported by convincing evidence in the following settings: anti-PD-1/PD-L1 monoclonal antibody (mAb) therapy for treating advanced melanoma and non-small cell lung cancer (NSCLC), the combination of rituximab and chemotherapy for treating chronic lymphocytic leukemia and B-cell non-Hodgkin's lymphoma, adoptive cell immunotherapy for NSCLC, and the combination of interferon α and chemotherapy for metastatic melanoma. A further meta-analysis of 16 RCTs showed that anti-PD-1/PD-L1 mAb therapy had a benefit in patients with solid tumors (overall survival; hazard ratio = 0.73, 95% CI: 0.68–0.79; p < 0.001), supported by convincing evidence. In the future, rigorous approaches are needed when interpreting meta-analyses to gain better insight into the true efficacy of cancer immunotherapy. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of interferons
*THERAPEUTIC use of monoclonal antibodies
*RITUXIMAB
*ANTINEOPLASTIC agents
*CANCER chemotherapy
*CHRONIC lymphocytic leukemia
*CONFIDENCE intervals
*IMMUNOTHERAPY
*LUNG cancer
*LYMPHOMAS
*MEDLINE
*MELANOMA
*METASTASIS
*ONLINE information services
*SURVIVAL
*TUMORS
*SYSTEMATIC reviews
*TREATMENT effectiveness
*DESCRIPTIVE statistics
Subjects
Details
- Language :
- English
- ISSN :
- 20726694
- Volume :
- 11
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 139863603
- Full Text :
- https://doi.org/10.3390/cancers11111801