Synthesis and iron coordination properties of schizokinen and its imide derivative.

The iron(III) affinity constants for schizokinen and its imide derivative are reported for the first time. Surprisingly, schizokinen possesses a higher affinity for iron(III) than desferrioxamine B; log KFeIII (FeL), 36.2 and 30.6, respectively. This increase in value is associated with the substitution of one hydroxamate function by an α-hydroxycarboxylate grouping. By virtue of the similarity of siderophore–iron(III) complexes and siderophore–gallium(III) complexes, schizokinen (which is a Gram positive siderophore) has potential for 68Ga PET-based imaging. [ABSTRACT FROM AUTHOR]