Back to Search
Start Over
Pediatric Bacterial Meningitis Surveillance in Nigeria From 2010 to 2016, Prior to and During the Phased Introduction of the 10-Valent Pneumococcal Conjugate Vaccine.
- Source :
-
Clinical Infectious Diseases . 2019 Supplement, pS81-S88. 8p. - Publication Year :
- 2019
-
Abstract
- Background: Historically, Nigeria has experienced large bacterial meningitis outbreaks with high mortality in children. Streptococcus pneumoniae (pneumococcus), Neisseria meningitidis (meningococcus), and Haemophilus influenzae are major causes of this invasive disease. In collaboration with the World Health Organization, we conducted longitudinal surveillance in sentinel hospitals within Nigeria to establish the burden of pediatric bacterial meningitis (PBM). Methods: From 2010 to 2016, cerebrospinal fluid was collected from children <5 years of age, admitted to 5 sentinel hospitals in 5 Nigerian states. Microbiological and latex agglutination techniques were performed to detect the presence of pneumococcus, meningococcus, and H. influenzae. Species-specific polymerase chain reaction and serotyping/grouping were conducted to determine specific causative agents of PBM. Results: A total of 5134 children with suspected meningitis were enrolled at the participating hospitals; of these 153 (2.9%) were confirmed PBM cases. The mortality rate for those infected was 15.0% (23/153). The dominant pathogen was pneumococcus (46.4%: 71/153) followed by meningococcus (34.6%: 53/153) and H. influenzae (19.0%: 29/153). Nearly half the pneumococcal meningitis cases successfully serotyped (46.4%: 13/28) were caused by serotypes that are included in the 10-valent pneumococcal conjugate vaccine. The most prevalent meningococcal and H. influenzae strains were serogroup W and serotype b, respectively. Conclusions: Vaccine-type bacterial meningitis continues to be common among children <5 years in Nigeria. Challenges with vaccine introduction and coverage may explain some of these finding. Continued surveillance is needed to determine the distribution of serotypes/groups of meningeal pathogens across Nigeria and help inform and sustain vaccination policies in the country. Streptococcus pneumoniae was the predominant pathogen responsible pediatric bacterial meningitis (46.4%: 71/153) during longitudinal sentinel surveillance within Nigeria, from 2010 to 2016. However, with the introduction of PCV10 across Nigeria, it is hoped that rates of pneumococcal meningitis will decline. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VACCINATION policies
*AGGLUTINATION tests
*HAEMOPHILUS influenzae
*HOSPITAL admission & discharge
*INTERPROFESSIONAL relations
*LONGITUDINAL method
*HEALTH policy
*NEISSERIA
*PATIENTS
*PNEUMOCOCCAL vaccines
*POLYMERASE chain reaction
*PUBLIC health surveillance
*STREPTOCOCCUS
*VACCINATION
*DISEASE prevalence
*SEROTYPING
*BACTERIAL meningitis
*CHILDREN
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Database :
- Academic Search Index
- Journal :
- Clinical Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 139888306
- Full Text :
- https://doi.org/10.1093/cid/ciz474