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Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues.
- Source :
-
Development (09501991) . Jul2004, Vol. 131 Issue 13, p3047-3055. 9p. 7 Color Photographs, 1 Diagram, 2 Graphs. - Publication Year :
- 2004
-
Abstract
- Mammary gland development is a complex process that is dependent on interactions between the developing mammary epithelium and the surrounding stromal tissues. We show that mice lacking the triglyceride synthesis enzyme acyl CoA:diacylglycerol transferase 1 (DGAT1) have impaired mammary gland development, characterized by decreased epithelial proliferation and alveolar development, and reduced expression of markers of functional differentiation. Transplantation studies demonstrate that the impaired development results from a deficiency of DGAT1 in both the stromal and epithelial tissues. Our findings are the first to link defects in stromal lipid metabolism to impaired mammary gland development. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MAMMARY glands
*EPITHELIUM
*TRIGLYCERIDES
*METABOLISM
*TISSUES
Subjects
Details
- Language :
- English
- ISSN :
- 09501991
- Volume :
- 131
- Issue :
- 13
- Database :
- Academic Search Index
- Journal :
- Development (09501991)
- Publication Type :
- Academic Journal
- Accession number :
- 14024865
- Full Text :
- https://doi.org/10.1242/dev.01158