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Vitamin D binding protein is required to utilize skin-generated vitamin D.
- Source :
-
Proceedings of the National Academy of Sciences of the United States of America . 12/3/2019, Vol. 116 Issue 49, p24527-24532. 6p. - Publication Year :
- 2019
-
Abstract
- Vitamin D is produced in the skin following exposure to sunlight. Ultraviolet (UV) B (UVB, 280–310 nm) results in isomerization of 7-dehydrocholesterol to previtamin D that spontaneously isomerizes to vitamin D. This pool of skin-derived vitamin D is the major source of vitamin D for animals. However, the mechanisms by which it becomes available remain undefined. It has been assumed that cutaneous vitamin D is transported into the circulation by vitamin D binding protein (DBP), but experimental evidence is lacking. To determine whether cutaneous vitamin D is transported by DBP, we utilized DBP−/− mice that were made vitamin D-deficient. These animals lack measurable 25(OH)D in blood and are hypocalcemic. As controls, DBP+/+ animals were vitamin D depleted and made equally hypocalcemic. UV irradiation of DBP+/+ animals restored serum calcium and serum 25(OH)D while the same treatment of DBP−/− animals failed to show either a serum calcium or 25(OH)D response despite having normal vitamin D production in skin. Intravenous injection of small amounts of recombinant DBP to the vitamin D-deficient DBP−/− mice restored the response to UV light. These results demonstrate a requirement for DBP to utilize cutaneously produced vitamin D. [ABSTRACT FROM AUTHOR]
- Subjects :
- *VITAMIN D
*CARRIER proteins
*VITAMINS
*ANIMAL welfare
*INTRAVENOUS injections
Subjects
Details
- Language :
- English
- ISSN :
- 00278424
- Volume :
- 116
- Issue :
- 49
- Database :
- Academic Search Index
- Journal :
- Proceedings of the National Academy of Sciences of the United States of America
- Publication Type :
- Academic Journal
- Accession number :
- 140260047
- Full Text :
- https://doi.org/10.1073/pnas.1915442116