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Grading Pancreatic Neuroendocrine Tumors by Ki-67 Index Evaluated on Fine-Needle Aspiration Cell Block Material.
- Source :
-
American Journal of Clinical Pathology . Jan2020, Vol. 153 Issue 1, p74-81. 8p. 2 Color Photographs, 3 Charts. - Publication Year :
- 2020
-
Abstract
- <bold>Objectives: </bold>This study aimed to determine whether Ki-67 index evaluated on cytologic material could reliably grade pancreatic neuroendocrine tumors (PanNETs).<bold>Methods: </bold>Cases with adequate cell block and available surgical specimens were included. Ki-67 index was calculated using "eyeballing," "hot spot," and "complete" counting methods.<bold>Results: </bold>The overall concordance rates between cytology and surgical specimens were 71%, 73%, and 59%, respectively, by using eyeballing, hot spot, and complete counting approaches. All grade 1 tumors were correctly graded on cytology, but in grade 2 tumors concordance rates were only 36%, 41%, and 9%, respectively. All grade 2 tumors were undergraded when cell blocks contained fewer than 1,000 cells, while concordance rate increased to 57%, 64%, and 14%, respectively, in cases with 1,000 cells or more.<bold>Conclusions: </bold>Grade 2 PanNETs can be significantly undergraded when Ki-67 index is evaluated on cell block material. In cases with 1,000 or more cells, the hot spot counting method has better correlation with surgical specimens. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NEUROENDOCRINE tumors
*PANCREATIC tumors
*ISLANDS of Langerhans tumors
*TUMOR grading
*NEEDLE biopsy
*CYTOLOGICAL techniques
*COLLECTION & preservation of biological specimens
*COMPARATIVE studies
*CYTOLOGY
*RESEARCH methodology
*MEDICAL cooperation
*PANCREAS
*RESEARCH
*TUMOR markers
*EVALUATION research
Subjects
Details
- Language :
- English
- ISSN :
- 00029173
- Volume :
- 153
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- American Journal of Clinical Pathology
- Publication Type :
- Academic Journal
- Accession number :
- 140381855
- Full Text :
- https://doi.org/10.1093/ajcp/aqz110