不同血液净化方式对中毒所致多器官功能障碍的临床效果比较.

Objective: To investigate the clinical effect and safety of different blood purifications on the patients with multiple organ dysfunction syndrome caused by poisoning. Methods: From September 2015 to September 2018, 41 patients diagnosed as multiple organ dysfunction syndrome caused by poisoning were retrospectively analyzed. All the patients were divided into two groups by different blood purifications: experimental group (sequential blood purification group) or control group (single blood purification group). The clinical outcomes were evaluated by general situation (hospitalization time and hospitalization costs) and main blood indicators, APACHE Ⅱ score and survival rates after treatment. Results: Compared with the control group, the ALT, AST, CK-MB, LDH, Cr, Bun levels and APACHE Ⅱ score of treatment group were significantly lower than those of the control group after 5 days of treatment (P< 0.05). The hospitalization cost of treatment group was higher than taht of the control group(P<0.05), while the length of hospital stay and the mortality of treatment group showed no significant difference between two groups (P>0.05). Conclusion: Compared with the single mode of blood purification, sequential therapy can significantly improve the hepatic function, reduce the APACHE II score for poisoning MODS, though it is more expensive, it won't increase the hospitalization time. [ABSTRACT FROM AUTHOR]