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Searching for Small Molecules with an Atomic Sort.
- Source :
-
Angewandte Chemie International Edition . 1/13/2020, Vol. 59 Issue 3, p1144-1148. 5p. - Publication Year :
- 2020
-
Abstract
- The discovery of biologically active small molecules requires sifting through large amounts of data to identify unique or unusual arrangements of atoms. Here, we develop, test and evaluate an atom‐based sort to identify novel features of secondary metabolites and demonstrate its use to evaluate novelty in marine microbial and sponge extracts. This study outlines an important ongoing advance towards the translation of autonomous systems to identify, and ultimately elucidate, atomic novelty within a complex mixture of small molecules. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14337851
- Volume :
- 59
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Angewandte Chemie International Edition
- Publication Type :
- Academic Journal
- Accession number :
- 141032548
- Full Text :
- https://doi.org/10.1002/anie.201911862