Adult Medulloblastoma: Report of two cases.

BACKGROUND Medulloblastoma is a primitive neuroectodermal tumor (PNET) characterized by both radiosensitivity and chemosensitivity. Usually it occurs in the pediatric age while it remains unusual in adults. We report 2 cases of adult medulloblastoma in order to discuss epidemiological, clinical and therapeutic features of this rare entity. PRESENTATION OF CASES : Mr T. A., 22 years old, had in July 2014 an excisional surgery of a cerebellar mass and histopathology showed a grade IV desmoplastic medulloblastoma. The resection was macroscopically complete. He started adjuvant radiotherapy 45 days after surgery. He received a dose of 54 Gy on the tumor bed and 34 Gy on the cerebrospinal axis. The MRI performed at the end of the radiotherapy revealed a residual mass of 1.5 cm. The patient was classified as a high risk group. He had 6 cycles of Etoposide Carboplatin with complete response. He is in complete remission since 4 years. Mrs T.M, 30 years old, presented with a 3 months history of headaches and vomiting. At the end of the explorations, the diagnosis of grade IV desmoplatic medulloblastoma was established. She underwent surgical resection of a cerebellar mass with no tumoral margins. The examination of the cerebrospinal fluid during the initial workup could not be done, so the patient was classified in the high-risk group. Conclusion : Because adult medulloblastoma is not common, the optimal treatment strategy has not been established. More prospective trials are required to better define it. [ABSTRACT FROM AUTHOR]