Reply to "MDPV-induced aggression in humans not established".

However, the 20 mg dose is not the highest ever dose reported, as stated by the authors. As well as this, the authors only considered the dose of 10 mg/kg, but the protocol began at 0.01 mg/kg, which corresponds to a human dose of 0.7 mg (following the example of the authors), and continued with 0.1 mg/kg, which corresponds to a human dose of 7 mg. Furthermore, in the study, we avoided using an aggression threshold (e.g. considering only those mice that bit 10 times in 5 minutes) [[10]], but we considered all resident mice that showed aggression (whether low, normal or high aggression; see Supplementary Materials). Serotonin transporter selectivity is crucial when discussing aggressive and violent behaviour due to the fact that, as already described, the serotoninergic system generally reduces aggression so that high levels of aggressiveness are correlated with low cerebrospinal fluid concentrations of 5-hydroxyindoleacetic acid, the serotonin metabolite [[14]]. [Extracted from the article]