New sights in cancer: Component and function of N6-methyladenosine modification.

• M6A is a revisable and dynamic RNA modification which affect large amounts of mRNA and non-coding RNA. • The "writing", "erasing" and "reading" of m6A modification have great impact on biological process. • Enzymes involved in the methylation exert synergistic or opposite impact on cancer progression. M6A is the most prevalent modification among epigenetics. M6A occurs on different sites of RNA and exerts important functions in specific circumstances, such as mRNA splicing, stability, nuclear export, translation or damage response. Different aspects of the concrete machinery of m6A modification have been studied, including its writing, erasing and reading capabilities. The molecular and biological functions of the m6A modification and enzymes, as well as their functions in different cancers have been substantially published. The present review summarizes these findings and provides clear description of the problems involved. The probable roles of m6A modification may acts on other cancers, suggesting that it may be a treatment target for these cancers. [ABSTRACT FROM AUTHOR]