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Mini-pillar microarray for individually electrochemical sensing in microdroplets.
- Source :
-
Biosensors & Bioelectronics . Feb2020, Vol. 149, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- High throughput and high sensitivity are two important aspects in multiple biomarker recognition, drug discovery and relevant biochemical sensing. Here, we integrate mini-pillar microarray with the circuit components toward high-throughput individual electrochemical sensing in microdroplets. On such droplet-microarray-based electrochemical platform, the high adhesion of the mini-pillar can hold a microdroplet (hundreds nanoliter to a few microliter) regardless of rotation and deformation. Each pillar as a unit has a three-electrode to achieve individual electrochemical sensing, and electrodes are integrated on one side to achieve the sequential electrochemical read-out. Qualitative and quantitative electrochemical assessments of multiple glucose concentrations in individual microdroplets are also achieved. Such mini-pillar-based individual electrochemical platform shows great potential in high-throughput and high-sensitive biomolecular recognitions, provides an opportunity to develop miniaturized sensing platform for emerging biological and pathological applications. • A mini-pillar-array electrochemical sensor is designed. • The mini-pillar-based electrochemical sensor can anchor the microliter droplets for high throughput biosensing. • The mini-pillar-based platform can achieve sensing of multiple glucose concentrations in array microdroplets. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MOLECULAR recognition
*ELECTROCHEMICAL sensors
*MICRODROPLETS
Subjects
Details
- Language :
- English
- ISSN :
- 09565663
- Volume :
- 149
- Database :
- Academic Search Index
- Journal :
- Biosensors & Bioelectronics
- Publication Type :
- Academic Journal
- Accession number :
- 141111910
- Full Text :
- https://doi.org/10.1016/j.bios.2019.111845