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The truncated E protein of DTMUV provide protection in young ducks.
- Source :
-
Veterinary Microbiology . Jan2020, Vol. 240, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- • C-terminally truncated E protein, prM-E and E proteins were constructed and applied as subunit vaccine candidates. • The constructed proteins could induce specific antibody responses and provide full protection against DTMUV infection. • The truncated E protein was suggested to be able to serve as a practical subunit vaccine candidate. Duck Tembusu virus (DTMUV) is a major pathogen of duck industry in China. In the current study, we generated different constructs containing envelope (E) protein, pre-membrane-envelope (prM-E) protein, and C-terminally truncated E protein of the DTMUV. The constructed proteins could induce specific antibody responses in young ducks. When ducklings were immunized with the constructed proteins, they were 100% protected against DTMUV infection. Furthermore, the fluorescent signal of the truncated E protein was stronger than other constructed proteins, when Bac-to-Bac baculovirus expression system was applied. Our data demonstrated that the truncated E protein used in the current study could be applied as a potential vaccine candidate to control DTMUV infection in young ducks. [ABSTRACT FROM AUTHOR]
- Subjects :
- *DUCK plague
*PROTEINS
*ANTIBODY formation
*DUCKLINGS
*INFECTION prevention
Subjects
Details
- Language :
- English
- ISSN :
- 03781135
- Volume :
- 240
- Database :
- Academic Search Index
- Journal :
- Veterinary Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 141129419
- Full Text :
- https://doi.org/10.1016/j.vetmic.2019.108508