Dysgeusia, from angiotensin-converting enzyme inhibitor to acute kidney injury - a case report.

Dysgeusia, the alteration of taste perception, may occur in the setting of various pathologies and is a relatively common adverse drug reaction. Dysgeusia may lead to changes in dietary intake resulting in malnutrition or weight gain. Older patients seem to be at an increased risk of developing dysgeusia and consequently, malnutrition and severe dehy-dration. Angiotensin-converting enzyme inhibitor-induced dysgeusia has been reported in up to 4% of patients undergoing ACEi treatment but is self-limiting despite continued use and resolves within a couple of months. The definite cause of ACEi-induced dysgeusia is yet to be settled, though salivary gland zinc ion chelation has been incriminated; more research is required. We present the case of a patient who developed dysgeusia after initiation of treatment with perindopril, which led to severe dehydration and acute kidney injury. [ABSTRACT FROM AUTHOR]