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Emtricitabine-induced pure red cell aplasia.
- Source :
-
Southern African Journal of HIV Medicine . 2019, Vol. 20 Issue 1, p1-3. 3p. - Publication Year :
- 2019
-
Abstract
- Introduction: Anemia is common in HIV. Parvo B19 infection is a well-recognised cause of red cell aplasia. Other causes of persistent pure red cell aplasia (PRCA) include anti-retroviral drugs such as zidovudine and lamivudine. We describe a case of PRCA that strongly implicates emtricitabine as the probable cause. Patient presentation: Patient was HIV positive and on treatment with a fixed drug combination consisting of tenofovir, emtricitabine and efavirenz for 3 months when she developed severe transfusion dependent anemia. The anemia, attributed to PRCA, was persistent and transfusion dependent for about one year. Management and outcome: Replacement of emtricitabine with abacavir resulted in a prompt, complete and lasting resolution of the anaemia, suggesting an etiologic role of emtricitabine in the PRCA. Conclusion: Emtricitibine is a rare cause of pure red cell aplasia. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PURE red cell aplasia
*DRUG side effects
*ERYTHROCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 16089693
- Volume :
- 20
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Southern African Journal of HIV Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 141255725
- Full Text :
- https://doi.org/10.4102/sajhivmed.v20i1.983