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Variegatic acid from the edible mushroom Tylopilus ballouii inhibits TNF-α production and PKCβ1 activity in leukemia cells.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Feb2020, Vol. 30 Issue 4, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Variegatic acid is inhibitor of β-hexosaminidase release and TNF-α secretion from RBL-2H3 cells, the inhibitory mechanism involved inhibition of PKCβ. • Anti-inflammatory effect of variegatic acid was studied in RBL-2H3 cells. • Inhibitory effects were observable after the increase of intracellular Ca2+ ion. • It suppressed degranulation & inflammatory cytokine secretion via PKCβ1 inhibition. • Variegatic acid could be a possible candidate for new anti-allergic agent. Variegatic acid, isolated from Tylopilus ballouii dry fruiting bodies, is an inhibitor of β-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL-2H3) cells, with IC 50 values of 10.4 μM and 16.8 μM, respectively. On the other hand, it inhibits PKCβ1 activity with an IC 50 value of 36.2 μM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 30
- Issue :
- 4
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 141380045
- Full Text :
- https://doi.org/10.1016/j.bmcl.2019.126886