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Distribution of quetiapine and metabolites in biological fluids and tissues.
- Source :
-
Forensic Science International . Feb2020, Vol. 307, pN.PAG-N.PAG. 1p. - Publication Year :
- 2020
-
Abstract
- Quetiapine is an atypical antipsychotic drug, frequently found in post-mortem samples. The quantitative determination of active metabolites may help in the interpretation of the potential toxic effects of the parent drug and its role in death. A fully validated LC-MS/MS method was developed for the identification and quantification of quetiapine and two main metabolites (N-desalkylquetiapine and 7-hydroxyquetiapine) in blood, biological fluids and tissues. Then, the distribution of analytes in different matrices was evaluated. LODs of 0.9, 0.3 and 0.3ng/mL were calculated for quetiapine, N-desalkylquetiapine and 7-hydroxyquetiapine respectively; while a LOQ at the concentration of 10.0ng/mL was defined for the three analytes. 13 post-mortem positive real cases have been included in the experiment. The results revealed that quetiapine and N-desalkylquetiapine might undergo a significant post-mortem redistribution, while 7-hydroxyquetiapine is less affected by this factor. N-desalkylquetiapine could be found in blood in relatively high concentrations in comparison to those of quetiapine; therefore, it should be always advisable to measure both the analytes. The analysis of tissues could provide additional data on potential intoxication with quetiapine. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 03790738
- Volume :
- 307
- Database :
- Academic Search Index
- Journal :
- Forensic Science International
- Publication Type :
- Academic Journal
- Accession number :
- 141399826
- Full Text :
- https://doi.org/10.1016/j.forsciint.2019.110108