Transition‐Metal‐Free Synthesis of Electron Rich 1,3‐Dienes via Base Promoted Isomerization of Propargylic Ethers.

Herein, a novel and scalable synthesis of electron rich 1,3‐dienes based on KOtBu mediated isomerization of propargylic ether derivatives was developed. This new process features easy handling reaction conditions, transition‐metal‐free isomerization, high isolated yields, and most of all, it could be used for modification of natural products at late stage functionalizations. [ABSTRACT FROM AUTHOR]