One-pot synthesis of 3-haloflavones from flavones using Oxone® and potassium halide as a halogenation reagent.

• 3-Haloflavones were synthesized from the corresponding flavones. • This method use Oxone® and potassium halide as a halogenation reagent. • 3-Chloro, 3-bromo and 3-iodo flavones can be conveniently synthesized. A two-step, one-pot method has been developed for the synthesis of 3-haloflavones from the corresponding flavones. The method uses Oxone® and potassium halide to produce the active molecular halogen in situ. The solvent (methanol) then participates in the reaction to afford the 2-methoxy-3-haloflavanone derivative. After adding sodium hydroxide, the corresponding 3-haloflavone product is obtained in good to excellent yields. This method provides a convenient synthesis of 3-chloro, 3-bromo and 3-iodo flavones from the same flavone starting material. [ABSTRACT FROM AUTHOR]