Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity.

The article presents a study on how retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity. Topics discussed include unrecognized spatiotemporally-predominant mechanism that shall inform future translational efforts; Therapeutic strategies based on these noncardiomyocytes, and remain underexplored; and elucidate the disease mechanisms and to search for potential therapeutic targets, several genetic strategies.