P-19 Sporotrichosis in São Paulo (Brazil): clinical and epidemiological features.

Human and animal sporotrichosis is a relatively common zoonotic disease in the southwest region of Brazil. In a recent outbreak (1999–2000) involving 66 humans in Rio de Janeiro, 79% of patients reported previous contact with infected cats. Over a 17-year period (1986–2002), 25 cases of feline sporotrichosis were diagnosed at our hospital (1.5 cases/year). Among these cases, 80% were male and had the cutaneous form of the disease, and 21 cases (84%) were in mixed-breed animals. The diagnosis was established based on histopathology (H&E and PAS stain) as well as fungal culture (95%) and cytologic examination (82.5%) of the cases. In the 25 homes of these animals, 15 (60%) were sporotrichosis cases of in-contact animals. Humans were infected in seven (28.5%) of the homes. Eighteen of the 49 dogs and cats (36.7%) in homes with infected humans were also affected. Itraconazole at 10 mg/kg once daily was successful even in FIV and FeLV positive cats. Funding: Self-funded. [ABSTRACT FROM AUTHOR]