Back to Search
Start Over
Clinical outcome and comparison between squamous and non-squamous cell carcinoma of the larynx.
- Source :
-
Acta Oto-Laryngologica . Feb2020, Vol. 140 Issue 2, p195-201. 7p. - Publication Year :
- 2020
-
Abstract
- Background: The various pathological types of non-squamous cell carcinomas (nSCCs) of the larynx accounted for about 5% laryngeal malignancies, but the knowledge regarding these pathological behaviors, therapeutic models and prognostic factors was limited. Objectives: To investigate the clinical characteristics and the survival outcomes of nSCCs of the larynx. Material and methods: A total of 106 patients diagnosed with laryngeal nSCC between 2003 and 2014 were retrospectively investigated from a cohort of 4,796 patients with laryngeal malignancies. Results: Spindle cell carcinoma, malignant salivary gland carcinoma, neuroendocrine carcinoma, non-Hodgkin's lymphomas, and carcinosarcoma accounted for the majority of the nSCCs of the larynx. In laryngeal nSCCs (excluding non-Hodgkin lymphomas), there was no significant difference in overall survival (OS) by tumor subsite (p =.818), clinical-stage (p =.051) or T stage (p =.412), but the difference in OS by N stage was statistically significant (p =.001). Upon comparison of propensity score-matched groups, the OS was longer in SCCs of the larynx (p =.0004). Conclusions and significance: Primary nSCC of the larynx is rare, and its diagnosis depends on comprehensive immunohistochemical examination, as the clinical characteristics are non-specific compared with SCC. The overall prognosis of nSCC is relatively poor compared with that of SCC in the larynx. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00016489
- Volume :
- 140
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Acta Oto-Laryngologica
- Publication Type :
- Academic Journal
- Accession number :
- 141627058
- Full Text :
- https://doi.org/10.1080/00016489.2019.1700305